Chem 351 Lectures - Spring 2007
No |
Date | Topics |
Chapter in Smith |
Lecture Notes, Powerpoints, etc. |
1 |
1/17 | E/Z designations for alkene stereoisomers. Physical properties of alkenes. | 10 | |
2 |
1/19 | Cis/trans isomerization. Fatty acids, retinal, hula twist. | 10 | Powerpoints |
3 |
1/22 | Preparation of alkenes. Reactions of alkenes: HX addition. | 10 | |
4 |
1/24 | Reactions of alkenes: halogenation, halohydrin formation. | 10 | notes for lectures 1-4 |
5 |
1/26 | Reactions of alkenes: hydration. | 10 | notes |
6 |
1/29 | More on Alkene Hydroboration. Intro to Alkynes. | 10, 11 | notes part 1 |
7 |
1/31 | Alkyne reactions. | 11 | notes |
8 |
2/2 | Alkynide chemistry. Overview of redox rxns. Reduction of alkenes and alkynes. | 11, 12 | notes part 1 |
9 |
2/5 | Mechanism of dissolving metal reduction. Reduction of alkyl halides. Epoxidation of alkenes. | 12 | notes |
10 |
2/7 | Dihydroxylation of alkenes. Ozonolysis. | 12 | notes |
| 11 | 2/9 | Sharpless oxidation. | 12 | notes |
|
|
2/12 | Exam 1 | answers | |
12 |
2/14 | Radical reactions. Halogenation. | 13 | notes |
13 |
2/16 | Mechanism of halogenation. Selectivity of Br vs Cl. | 13 | notes |
14 |
2/19 | NBS for allylic bromination. Radical structure. Lipid peroxidation. Peroxide effect on HBr additions. | 13 | notes |
15 |
2/21 | Conjugation. Allylic cations and radicals. 1,2 vs 1,4 addition to conjugated dienes. | 16 | notes |
16 |
2/23 | Benzene. Naming of substituted benzenes. Other aromatic compounds. | 17 | notes |
17 |
2/26 | More on aromaticity. The basis for Huckel's rule. | 17 | notes |
18 |
2/28 | More on MO theory. Polycyclic aromatic hydrocarbons. | 17 | notes |
| 3/2 | Exam 2 | |||
| 19 | 3/12 | Electrophilic aromatic substitution. Friedel-Crafts reactions. | 18 | notes |
|
20 |
3/14 | Other EAS reactions. Halogenation, Nitration, Sulfonation, Deuteronation. | 18 | notes |
21 |
3/16 | Effects of substituents in EAS reactions. | 18 | notes |
22 |
3/19 | EAS reactions on Disubsituted Benzenes. Other reactions of benzene ring compounds. Synthesis. | 18 | notes |
23 |
3/21 | Benzene diazonium chemistry. Effects of substituents in the Diels-Alder reaction. | 25, 16 | notes |
24 |
3/23 | Carboxylic Acids - naming and acidity. | 19 | notes |
|
25 |
3/26 | Sulfonic acids. Amino acids. Intro to Organometallic Chemistry. | 19, 20 | notes |
26 |
3/28 | The Grignard synthesis of alcohols. | 20 | notes |
27 |
3/30 | Organocuprates. Intro to Aldehydes and Ketones. | 20, 21 | notes |
| 28 | 4/2 | Nucleophilic addition to aldehydes and ketones. | 21 | notes |
| 4/4 | Exam 3 | |||
29 |
4/9 | Acid-catalyzed addition of water and alcohols to aldehydes and ketones. Acetals. Protecting groups. | 21 | notes |
30 |
4/11 | Naming of carboxylic acid derivatives. | 22 | notes |
|
31 |
4/13 | Reactions and preparation of carboxylic acid derivatives. SNacyl. Thionyl chloride for acyl chloride preparation. | 22 | notes |
| 32 | 4/16 | Anhydrides as acylating agents. Hydrolysis of nitriles. | 22 | notes |
| 33 | 4/18 | Enols and enolates as nucleophiles. Bases to use for enolate formation. Halogenation. Alkylation. Kinetic vs thermodynamic enolate. | 23 | notes |
| 34 | 4/20 | Alkylation of enolates. Alkylation of enamines. Malonic ester synthesis. Aldol reaction. | 23, 24 | notes |
| 35 | 4/23 | 24 | notes | |
| 36 | 4/25 | 24 | notes | |
| 4/27 | Exam 4 | 21-24 | ||
| 5/2 | Final Exam |
