Expt #3. Friedel Crafts
Acylation of Cumene
Relevant textbook reading - Brown and Poon,
Chapter 9.6-9.7
Overview - You will react propionyl chloride/AlCl3
with cumene and use NMR to determine the structure of the
obtained product. (The product structure is predictable
from the textbook reading assignment.)
Procedures
Running the reaction.
- Using the balance located in the dispensing fume
hood, weigh out 11 mmol AlCl3 into a dry
50-mL round bottom flask.
- Add a small stir bar and 10 mL dichloromethane
(DCM).
- Cautiously add 1.0 mL propionyl chloride.
- Attach a reflux condenser, Claisen adapter, and
addition funnel as shown in Fig 7.4a (p 63) in Mohrig.
- Prepare a solution of cumene (10 mmol) in 5 mL DCM
and add this to the addition funnel.
- Add the cumene solution dropwise over a period of
approx 5 min to the stirring solution.
- Stir for an additional 30 min.
Work-up procedures.
- Slowly add 7.5 mL cold water via the addition funnel
to stop the reaction and quench any left over acyl
chloride.
- Place the flask on an ice bath and slowly add 7.0 mL
concentrated HCl. At this point all of the aluminum
salts should have dissolved. If this is not the case
add another 0.5 mL of HCl.
- Transfer the reaction mixture to a separatory funnel
and drain the lower layer into a small Erlenmeyer
flask. Avoid getting any of the aqueous layer when
carrying out this step.
- Extract the aqueous layer with 5 mL additional DCM
and combine the organic layer with the previous
organic layer.
- Wash the combined organic layers with 5 mL 1% NaHCO3(aq).
Caution, CO2 gas is liberated here so the
separatory funnel will need to be vented early and
often.
- Dry the organic solution over Na2SO4.
- Use the rotary evaporator to remove the DCM solvent
in vacuo.
- Determine the yield.
Characterization
of Product
- Obtain the 1H and 13C NMR
spectrum using CDCl3 as the solvent.
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